Assistant Professor
Department of Molecular Genetics, Graduate School of Medicine, Kyoto University, Japan
Yusuke Shiromoto, Ph.D. Assistant Professor. Graduate School of Medicine, Kyoto University.
In vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) are two major assisted reproductive techniques (ARTs) widely used to treat infertility. ICSI offspring exhibited behavioral abnormalities. ICSI-F2 offspring showed various types of congenital abnormalities. My research is aimed at understanding the biological abnormalities caused by ART and their causes.
piRNAs suppress endogenous retrovirus to ensure gametogenesis. We revealed that piRNAs suppress pluripotency of the male germ cells. I am working to identify a novel function of piRNAs: the mechanism of pluripotency suppression in the germ line.