Scientist C Indian Council of Medical Research New Delhi, Delhi, India
Abstract Authors: Taruna Katyal1, Khurshid Ahmad Padder2, Nusrat Jahan2, Mohmad Aadil Yousuf2, Mohd Ashraf Ganie2
Affiliations:
1RCN Division, ICMR Headquarters, New Delhi, INDIA
2Department of Endocrinology, Sher-i- Kashmir Institute of Medical Sciences, Srinagar, INDIA.
Abstract Text: Vitamin D deficiency (VDD) is seen in 70 to 100% of apparently health population in India. Polycystic ovary syndrome (PCOS) is also in epidemic proportions in the country. VDD is incriminated in insulin resistance(IR), the central driver of PCOS pathophysiology, but data is scarce from our country. We aimed to assess the magnitude of VDD among Indian women with PCOS and also investigated its relation to clinical,biochemical,hormonal and IR markers. Among total of 2792 women aged 18-40 years, 860 were PCOS (Rottardam criteria, 2003), 758 pre-PCOS women and 1174 healthy controls. Detailed medical history, clinical examination, biochemical, hormonal, and IR parameters were assessed. Lips classification was used to assess Vitamin D status and weregraded asVD deficient (< 20ng/ml), VD insufficient (≥20-29ng/ml) and VD sufficient (≥30-100ng/ml). Student t-test and ANOVA were used to evaluate the differences in the means of various parameters. Correlations were investigated by Pearson Correlation.The mean age (29.21±6.63vs.30±6.13 years) and BMI (24.64±4.34 vs. 24.44± 4.18Kg/m2) of PCOS cases and controlswas comparable. The mean number of menstrual cycles per year(8.57±2.91vs.12±0.7;p< 0.001) was significantly lower while asmFG scores (5.86±5.76vs.1.08±2.13;p< 0.000) and serum total testosterone (0.52±0.27 vs. 0.27±0.13 ng/ml;p< 0.001) levels were significantly higheramong women with PCOS as compared to healthy women.The serum vitamin D3levels were lowest in the PCOS group (9.11±11.41) followed by Pre-PCOS group (16.11±10.86) and control group (17.20±10.80) (p< 0.001). The HOMA-IR (3.74± 4.39vs.3.40± 3.86;p< 0.000) was significantly elevated among VD deficient PCOS women than VD sufficient PCOS women (p< 0.021). The serum 25OHD3correlates positively with serum calcium (r=0.1445;p< 0.05), visceral adipose index (r=0.7289;p< 0.05), serum total cholesterol (r=0.2701;p< 0.05) and serum total triglyceride (r=0.5628; p< 0.05)and negatively with serum testosterone (r=-0.2131;p< 0.05).VDD is highly prevalent in PCOS women and the magnitude of VDD worsens the biochemical, hormonal and IR parameters among women with PCOS.
